The ALDH2and DRD2ANKK1genes interacted in bipolar II but not bipolar I disorder

Clarifying the association between bipolar I and bipolar II, the two most common subtypes of bipolar disorder, at the genetic level is essential for improving our understanding of these disorders. The dopaminergic system has been implicated in the pathogenesis of bipolar disorder. It may be important to investigate genes involved in metabolizing dopamine and encoding dopamine receptors, such as the aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptorankyrin repeat and kinase domain containing 1 (DRD2ANKK1) genes. We examined the association of the ALDH2and DRD2ANKK1 Taq IApolymorphisms with bipolar I and II disorders and possible interactions between these genes.