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Pharmacogenomic characterization of gemcitabine response – a framework for data integration to enable personalized medicine

Authors :
Harris, Michael
Bhuvaneshwar, Krithika
Natarajan, Thanemozhi
Sheahan, Laura
Wang, Difei
Tadesse, Mahlet G.
Shoulson, Ira
Filice, Ross
Steadman, Kenneth
Pishvaian, Michael J.
Madhavan, Subha
Deeken, John
Source :
Pharmacogenetics and Genomics; February 2014, Vol. 24 Issue: 2 p81-93, 13p
Publication Year :
2014

Abstract

Response to the oncology drug gemcitabine may be variable in part due to genetic differences in the enzymes and transporters responsible for its metabolism and disposition. The aim of our in-silico study was to identify gene variants significantly associated with gemcitabine response that may help to personalize treatment in the clinic.

Details

Language :
English
ISSN :
17446872 and 17446880
Volume :
24
Issue :
2
Database :
Supplemental Index
Journal :
Pharmacogenetics and Genomics
Publication Type :
Periodical
Accession number :
ejs48718790
Full Text :
https://doi.org/10.1097/FPC.0000000000000015