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Acute myeloid leukemia with mutated NPM1diagnosis, prognosis and therapeutic perspectives
- Source :
- Current Opinion in Oncology; November 2009, Vol. 21 Issue: 6 p573-581, 9p
- Publication Year :
- 2009
-
Abstract
- Nucleophosmin (NPM1) gene mutations, which cause aberrant cytoplasmic expression of nucleophosmin (NPMc), are the most frequent genetic alteration in acute myeloid leukemia (AML), being found in about 30% cases. The present review summarizes recent advances in the biology, diagnosis, prognosis and therapy of NPM1-mutated AML.
Details
- Language :
- English
- ISSN :
- 10408746 and 1531703X
- Volume :
- 21
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Current Opinion in Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs48685181
- Full Text :
- https://doi.org/10.1097/CCO.0b013e3283313dfa