Effect of Autologous Platelet-Rich Plasma in Combination With Bovine Porous Bone Mineral and Bio-Guide Membrane on Bone Regeneration in Mandible Bicortical Bony Defects

Growth factors contained in platelet-rich plasma (PRP) can induce osteoblast differentiation in certain studies, whereas in others, osteogenesis of PRP on mandible bone defects has not been proved clinically. The aim of the study was to investigate the effect of autologous PRP on the osteogenic potential of combining bovine porous bone mineral (BPBM) and bio-guide membrane (BGM) in promoting mandible bicortical bony defects in rabbits.