Are TMEM genes potential candidate genes for panic disorder

We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2–q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132Eshowed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98and PD. Our data indicate that TMEM132Emight contribute moderately towards the risk of developing PD.