Negative Predictive Value of IL28B, SLC28A2, and CYP27B1SNPs and Low RBV Plasma Exposure for Therapeutic Response to PEGIFN-RBV Treatment

Authors :: D'Avolio, Antonio
Ciancio, Alessia
Siccardi, Marco
Smedile, Antonina
Simiele, Marco
Cusato, Jessica
Baietto, Lorena
Marucco, Diego Aguilar
Cariti, Giuseppe
Calcagno, Andrea
Gonzalez de Requena, Daniel
Sciandra, Mauro
Troshina, Giulia
Caviglia, Gian Paolo
Bonora, Stefano
Rizzetto, Mario
Di Perri, Giovanni
Source :: Therapeutic Drug Monitoring; December 2012, Vol. 34 Issue: 6 p722-728, 7p
Publication Year :: 2012
Abstract: The response rate to treatment of chronic hepatitis C virus-genotype 1 and 4 infections was recently found to be strongly influenced by many polymorphisms. The aim of our study was to carry out an integrated analysis of the effects of polymorphisms and ribavirin (RBV) plasma exposure on outcome.

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