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Influence of Uridine Diphosphate Glucuronosyltransferase 2B7 −161C>T Polymorphism on the Concentration of Valproic Acid in Pediatric Epilepsy Patients
- Source :
- Therapeutic Drug Monitoring; June 2014, Vol. 36 Issue: 3 p406-409, 4p
- Publication Year :
- 2014
-
Abstract
- Valproic acid (VPA) is widely used to treat various types of epilepsy. Interindividual variability in VPA pharmacokinetics may arise from genetic polymorphisms of VPA-metabolizing enzymes. This study aimed to examine the relationships between plasma VPA concentrations and the −161C>T single nucleotide polymorphism in uridine diphosphate glucuronosyltransferase (UGT) 2B7 genes in pediatric epilepsy patients.
Details
- Language :
- English
- ISSN :
- 01634356 and 15363694
- Volume :
- 36
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Therapeutic Drug Monitoring
- Publication Type :
- Periodical
- Accession number :
- ejs48550350
- Full Text :
- https://doi.org/10.1097/FTD.0000000000000012