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Pharmacokinetics of Treosulfan in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation
- Source :
- Therapeutic Drug Monitoring; August 2014, Vol. 36 Issue: 4 p465-472, 8p
- Publication Year :
- 2014
-
Abstract
- High-dose treosulfan is used in conditioning regimens before hematopoietic stem cell transplantation in children. Pharmacokinetic data to optimize treosulfan dosing are scarce in this patient population. The aims of this study were the development and validation of an analytical method for treosulfan in human serum and the development of a pharmacokinetic model for treosulfan in pediatric patients. Furthermore, we aimed to develop a limited sampling strategy to estimate treosulfan systemic exposure with a minimum of inconvenience and risk for the patient.
Details
- Language :
- English
- ISSN :
- 01634356 and 15363694
- Volume :
- 36
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Therapeutic Drug Monitoring
- Publication Type :
- Periodical
- Accession number :
- ejs48550318
- Full Text :
- https://doi.org/10.1097/FTD.0000000000000047