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Molecular Genetic and Functional Characterization Implicate Muscle-Restricted Coiled-Coil Gene (MURC) as a Causal Gene for Familial Dilated Cardiomyopathy
- Source :
- Circulation: Cardiovascular Genetics; August 2011, Vol. 4 Issue: 4 p349-358, 10p
- Publication Year :
- 2011
-
Abstract
- Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are classic forms of systolic and diastolic heart failure, respectively. Mutations in genes encoding sarcomere and cytoskeletal proteins are major causes of HCM and DCM. MURC, encoding muscle-restricted coiled-coil, a Z-line protein, regulates cardiac function in mice. We investigated potential causal role of MURCin human cardiomyopathies.
Details
- Language :
- English
- ISSN :
- 1942325X
- Volume :
- 4
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Circulation: Cardiovascular Genetics
- Publication Type :
- Periodical
- Accession number :
- ejs48522514
- Full Text :
- https://doi.org/10.1161/CIRCGENETICS.111.959866