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Soluble Epoxide Hydrolase Gene Deletion Is Protective Against Experimental Cerebral Ischemia
- Source :
- Stroke (Ovid); July 2008, Vol. 39 Issue: 7 p2073-2078, 6p
- Publication Year :
- 2008
-
Abstract
- Cytochrome P450 epoxygenase metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are produced in the brain and perform important biological functions, including vasodilation and neuroprotection. However, EETs are rapidly metabolized via soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). We tested the hypothesis that sEH gene deletion is protective against focal cerebral ischemia through enhanced collateral blood flow.
Details
- Language :
- English
- ISSN :
- 00392499 and 15244628
- Volume :
- 39
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Stroke (Ovid)
- Publication Type :
- Periodical
- Accession number :
- ejs48321417
- Full Text :
- https://doi.org/10.1161/STROKEAHA.107.508325