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Segmental Variation in a Duplicated msp2Pseudogene Generates Anaplasma marginaleAntigenic Variants
- Source :
- Infection and Immunity; December 2018, Vol. 87 Issue: 2
- Publication Year :
- 2018
-
Abstract
- Anaplasma marginaleis a prototypical highly antigenically variant bacterial pathogen dependent on the sequential generation of major surface protein 2 (Msp2) outer membrane variants to establish persistent infection. Msp2 is encoded by a single expression site, and diversity is achieved by gene conversion of chromosomally encoded msp2pseudogenes.
Details
- Language :
- English
- ISSN :
- 00199567 and 10985522
- Volume :
- 87
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Infection and Immunity
- Publication Type :
- Periodical
- Accession number :
- ejs48210496
- Full Text :
- https://doi.org/10.1128/IAI.00727-18