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Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

Authors :
Dziekan, Jerzy M.
Yu, Han
Chen, Dan
Dai, Lingyun
Wirjanata, Grennady
Larsson, Andreas
Prabhu, Nayana
Sobota, Radoslaw M.
Bozdech, Zbynek
Nordlund, Pär
Source :
Science Translational Medicine; January 2019, Vol. 11 Issue: 473
Publication Year :
2019

Abstract

A cellular thermal shift assay (CETSA) protocol identifies and resolves antimalarial drug targets in P. falciparum.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
11
Issue :
473
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs47979780
Full Text :
https://doi.org/10.1126/scitranslmed.aau3174