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Monocyte chemoattractant protein-1 and secreted ectodomain of sialic acid-binding Ig-like lectin-9 enhance bone regeneration by inducing M2 macrophages
- Source :
- Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- The bone-healing process consists of a primary inflammatory phase and a subsequent anti-inflammatory bone-forming phase. It was recently suggested that macrophages play an indispensable role in bone healing. Macrophages are plastic immune cells consisting of several subtypes, including pro-inflammatory M1-type and anti-inflammatory M2-type macrophages. Recently, a set of M2 macrophage inducers was described, monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (sSiglec-9), and applied them to a rat spinal cord injury model. Here, we hypothesized that MCP-1/sSiglec-9 enhance bone regeneration by inducing M2 macrophages.
Details
- Language :
- English
- ISSN :
- 22125558
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
- Publication Type :
- Periodical
- Accession number :
- ejs47834531
- Full Text :
- https://doi.org/10.1016/j.ajoms.2018.12.007