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Parameters Associated With Mandibular Osteoradionecrosis

Parameters Associated With Mandibular Osteoradionecrosis

Authors :
Mendenhall, William M.
Suárez, Carlos
Genden, Eric M.
de Bree, Remco
Strojan, Primož
Langendijk, Johannes A.
Mäkitie, Antti A.
Smee, Robert
Eisbruch, Avraham
Lee, Anne W.M.
Rinaldo, Alessandra
Ferlito, Alfio
Source :
American Journal of Clinical Oncology: Cancer Clinical Trials; December 2018, Vol. 41 Issue: 12 p1276-1280, 5p
Publication Year :
2018

Abstract

The objective of this review is to discuss factors related to the risk of osteoradionecrosis (ORN) and how to minimize the likelihood of this complication. A PubMed search for publications pertaining to ORN within the last 3 years was conducted revealing 44 publications. The bibliographies of these publications were reviewed to identify additional references spanning a longer time period. The incidence of ORN is 5% to 10% with a median latency period of 1 to 2 years or less. The likelihood of ORN depends on a number of factors including primary site and extent of disease, dental status, treatment modality, radiotherapy (RT) dose, volume of mandible included in the planning target volume, RT fractionation schedule and technique, and teeth extractions. The risk of ORN may be reduced by limiting the RT dose and volume of mandible irradiated without increasing the risk of a local-regional recurrence due to a marginal miss.

Details

Language :
English
ISSN :
02773732 and 1537453X
Volume :
41
Issue :
12
Database :
Supplemental Index
Journal :
American Journal of Clinical Oncology: Cancer Clinical Trials
Publication Type :
Periodical
Accession number :
ejs47687304
Full Text :
https://doi.org/10.1097/COC.0000000000000424