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Rhodium-Catalyzed Tandem Reaction of Isocyanides with Azides and Oxygen Nucleophiles: Synthesis of Isoureas
- Source :
- The Journal of Organic Chemistry; December 2018, Vol. 84 Issue: 1 p53-59, 7p
- Publication Year :
- 2018
-
Abstract
- A novel rhodium-catalyzed tandem reaction of isocyanides with azides and various oxygen nucleophiles has been developed. The reaction provides a simple and highly efficient one-pot synthesis of various N-sulfonyl/acylisoureas with broad substrate scope in an atom-economical manner from readily available starting materials in a highly stereoselective manner.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 84
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- The Journal of Organic Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs47658737
- Full Text :
- https://doi.org/10.1021/acs.joc.8b01842