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Assembly of C3a-Peroxylated Pyrroloindolines via Interrupted Witkop Oxidation
- Source :
- Organic Letters; December 2018, Vol. 20 Issue: 24 p7937-7941, 5p
- Publication Year :
- 2018
-
Abstract
- The first synthetically useful interrupted Witkop oxidation has been disclosed through a radical triggered oxidative peroxycyclization of tryptamine derivatives, using a TBAI/TBHP catalytic system. This differs from known tryptophan oxidations, which typically cleave the 2,3-double bond. Upon one-pot reduction, this system renders an easy access to structurally distinct peroxypyrroloindoles, which are demonstrated to be useful precursors in various downstream synthetic elaborations.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 20
- Issue :
- 24
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs47451006
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b03509