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Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo
- Source :
- Journal of Investigative Dermatology; April 2019, Vol. 139 Issue: 4 p769-778, 10p
- Publication Year :
- 2019
-
Abstract
- Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model. We found that both Trm and Tcm sensed autoantigen in the skin long after stabilization of disease, producing IFN-γ, CXCL9, and CXCL10. Blockade of Tcm recruitment to the skin with FTY720 or depletion of Tcm with low-dose Thy1.1 antibody reversed disease, indicating that Trm cooperate with Tcm to maintain disease. Taken together, our data provide characterization of skin memory T cells in vitiligo, demonstrate that Trm and Tcm work together during disease, and indicate that targeting their survival or function may provide novel, durable treatment options for patients.
Details
- Language :
- English
- ISSN :
- 0022202X and 15231747
- Volume :
- 139
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Investigative Dermatology
- Publication Type :
- Periodical
- Accession number :
- ejs47371428
- Full Text :
- https://doi.org/10.1016/j.jid.2018.10.032