BIOLOGICAL ACTIVITIES OF A COMBINATION OF MEDROXYPROGESTERONE ACETATE AND ETHINYLOESTRADIOL

Combinations of medroxyprogesterone acetate (mg): ethinyloestradiol (μg) were studied in four different ratios, i. e. 2 : 75, 2.5 : 75, 5 : 75, 5 : 50. The ratios were administered up to the 200-fold dose per kg body weight and well tolerated.The combination of the two steroids led to a potentation of the antiovulatory and gonadotrophin inhibiting activity. No side-effects were detected. The data allow of the conclusion that the ratio 2 : 75 is sufficient to inhibit the central control mechanism and thus ovulation.