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Relation of immunoreactive gastric inhibitory polypeptide to changes in glycaemic control and B cell function in Type 1 (insulin-dependent) diabetes mellitus
- Source :
- European Journal of Endocrinology; February 1984, Vol. 105 Issue: 2 p221-225, 5p
- Publication Year :
- 1984
-
Abstract
- Abstract. The effect of strict glycaemic control on plasma immunoreactive gastric inhibitory polypeptide IR-GIP) concentrations and pancreatic B cell function as estimated by plasma C-peptide was evaluated in 14 Type 1 (insulin-dependent) diabetics. The effect was estimated by giving a test meal before (test 1) and after (test 2) 1 week with near normal blood glucose control (mean blood glucose 6.7 ± 0.2 mmol/l) and again 3 weeks later (test 3) in the outpatient clinic. The glycaemic control was significantly improved at test 2 and test 3 compared with that of test 1. The IR-GIP concentrations before and after the meals were similar at all three tests and not different from those found in 21 normal controls. In 8 patients with a significant B cell response at test 1, B cell function was significantly improved both at test 2 and test 3 but no change in fasting or post-prandial IR-GIP concentrations was found and no correlation between B cell function and IR-GIP existed.We conclude that strict glycaemic control improves B cell function but does not modulate plasma IR-GIP concentrations. Factors other than GIP seem to be of greater importance in determining the magnitude of B cell function in Type 1 diabetes.
Details
- Language :
- English
- ISSN :
- 08044643 and 1479683X
- Volume :
- 105
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- European Journal of Endocrinology
- Publication Type :
- Periodical
- Accession number :
- ejs46901896
- Full Text :
- https://doi.org/10.1530/acta.0.1050221