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Cobalt-Catalyzed α-Methoxymethylation and Aminomethylation of Ketones with Methanol as a C1 Source
- Source :
- Organic Letters; October 2018, Vol. 20 Issue: 21 p6774-6779, 6p
- Publication Year :
- 2018
-
Abstract
- Using methanol as a sustainable C1 source, cobalt-catalyzed α-methoxymethylation and α-aminomethylation of ketones have been developed. With cheap CoCl2·6H2O as catalyst and TBHP as oxidant, the methoxymethylated products were obtained within a short reaction time in up to 91% yield. Based on the observed reversibility of methoxy adduct to enone, the α-aminomethylation of ketones was then achieved by a one-pot methylenation/aza-Michael addition sequence. In addition, an easy way to convert α-methoxymethyl ketones to α-aminomethyl ketones has been discovered.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 20
- Issue :
- 21
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs46774480
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b02892