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Knockdown of a disintegrin A metalloprotease 12 (ADAM12) during adipogenesis reduces cell numbers, delays differentiation, and increases lipid accumulation in 3T3-L1 cells
- Source :
- Molecular Biology of the Cell; August 2018, Vol. 29 Issue: 15 p1839-1855, 17p
- Publication Year :
- 2018
-
Abstract
- We found that ADAM12 reduced cell numbers in proliferating preadipocytes, delayed differentiation of preadipocytes to adipocytes and increased lipid accumulation in mature adipocytes. ADAM12 knockdown impacted IGFBP/IGF/mTOR-growth and PPARĪ³ signalling pathways.
Details
- Language :
- English
- ISSN :
- 10591524 and 19394586
- Volume :
- 29
- Issue :
- 15
- Database :
- Supplemental Index
- Journal :
- Molecular Biology of the Cell
- Publication Type :
- Periodical
- Accession number :
- ejs46609045
- Full Text :
- https://doi.org/10.1091/mbc.E17-07-0471