Hect E3 ubiquitin ligase Tom1 controls Dia2 degradation during the cell cycle

This study identifies the degradation pathway for the F-box protein Dia2, which plays an important role in maintaining genomic integrity. The Hect domain E3 ligase Tom1 recognizes a stretch of positively charged residues in Dia2, leading to Dia2 degradation by the ubiquitin proteasome system. Failure to degrade Dia2 disrupts cell cycle dynamics.