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Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis
- Source :
- Organic Letters; September 2018, Vol. 20 Issue: 19 p5999-6002, 4p
- Publication Year :
- 2018
-
Abstract
- ApUGT, a diterpene glycosyltransferase from Andrographis paniculata, could transfer a glucose to the C-19 hydroxyl moiety of andrograpanin to form neoandrographolide. This glycosyltransferase has a broad substrate scope, and it can glycosylate 26 natural and unnatural compounds of different structural types. This study provides a basis for exploring the glycosylation mechanism of ent-labdane-type diterpenes and plays an important role in diversifying the structures used in drug discovery.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 20
- Issue :
- 19
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs46555923
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b02146