Skip to search
Skip to main content
Back to Search
Start Over
Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial
Authors :
O'Callaghan, Finbar J K Edwards, Stuart W Alber, Fabienne Dietrich Cortina Borja, Mario Hancock, Eleanor Johnson, Anthony L Kennedy, Colin R Likeman, Marcus Lux, Andrew L Mackay, Mark T Mallick, Andrew A Newton, Richard W Nolan, Melinda Pressler, Ronit Rating, Dietz Schmitt, Bernhard Verity, Christopher M Osborne, John P Abdel Aziz, Maysara Acharya, Triloknath Adcock, Carolyn Jones, Robert Howells, Rachel Marsh, Ben Adejare, Kemi Adiga, Rashmi Wheater, Mary Ahmed, Mansoor Sawal, Mohammad Goel, Chhavi Ahmed, MAS Alber, Michael Wolff, Markus Ruf, Susanne Al-Kharusi, Asya Al-Moasseb, Hassan Arora, Ruchi Beach, Richard Atkinson, Patricia Ayonrinde, Kunle Bala, Pronab Bamford, Nicola Barakat, Nagi Basheer, Nigel Baxter, Peter Mordekar, Santosh Rittey, Chris Borggraefe, Ingo Borusiak, Peter Cagnoli, Sabine Brown, Richard Calvert, Sophie Calvert, Sophie Cameron, Duncan Chaniyil, Ramesh Chinthapalli, Ravi Chow, Gabriel Whitehouse, William Clarke, Vinodhini Cooper, Chris Datta, Alexane D'Costa, Selwyn de Goede, Christian Basu, Helen Deekollu, David Della Marina, Adela Dison, Penelope Dunkley, Colin Eaton, Megan Ellison, Julie Pugh, Robert Fallon, Penny Faza, Hani Choonara, Imti Morton, Richard Ratnayaka, Mal Ferrie, Colin Freeman, Amanda Warriner, Stephen Garcia, Maria Ghazavi, Malihe Gibbon, Frances Gibbs, John Ginbey, Des Guarino, Iolanda Gupta, Rajesh Hanlon, Mary Harris, Siân Munyard, Paul Hemingway, Cheryl Eltze, Christin Kaliakatsos, Marios Murugan, Velayutham Robinson, Robert Tan, Jeen Hindley, Daniel Hughes, Adrian Hussain, Akmal Boden, Greg Hussain, Munir Hussain, Nahin Dabydeen, Lyvia Irwin, Kate Jacobs, Julia Jauhari, Praveen Minchom, Philip Jones, Simon Karenfort, Michael Keimer, Reinhard Kennedy, Colin Kirkham, Fenella Whitney, Andrea Kirkpatrick, Martin Jollands, Alice Kneen, Rachel Iyer, Anand McTague, Amy Spinty, Stefan Kumar, Ramesh Kurlemann, Gerhard Lee, Matthew Jurges, Eman Levy, Robert Lewis, Helen Lewis, Hilary Lewis, Hilary Lloyd Evans, Andrew Loh, Ne-Ron Osborne, John O'Callaghan, Finbar Maddicks, Hilary Luecke, Thomas Lux, Andrew O'Callaghan, Finbar Majumdar, Anirban Vijayakumar, Kayal MacKay, Mark Freeman, Jeremy Hayman, Michael Kornberg, Andrew Leventer, Rick Ryan, Monique Ware, Tyson Mancais, Penny Marinaki, Katina Massarano, Albert Mathew, Satheesh McLellan, Ailsa Melville, Colin Mewasingh, Leena Muhle, Hiltrud Nagmeldin, Eisawi Natarajan, Jeyashree Nelapatla, Suresh Gondwe, Jailosi Newton, Richard Hughes, Imelda Martland, Tim McCullagh, Gary Tan, Jeen Vassallo, Grace Nirmal, Stephen Nolan, Melinda Davis, Suzanne Patel, Rakesh Sharpe, Cynthia Olabi, Anas O'Neill, Kevin Gould, Jim Panzer, Axel Theophil, Manuela Parepalli, Srinivas Hinde, Frank Smith, Martin Parker, Alasdair Chitre, Manali Philip, Sunny Gupta, Rajat Wassmer, Evangeline Pike, Mike McShane, Tony Prakash, Nandhini Padmakumar, Beena Pridmore, Clair Prietsch, Viola Krieg, Peter Quinlivan, Ros Quinn, Michael Collinson, Andrew Howells, Rachel Rajalingam, Usha Rakshi, Karl Rao, Tekki Ravi, Asha Rifkin, Rob Roper, Helen Rowlandson, Piers Sadleir, Lynette Sahi, Sanjay Saraswatula, Arun O'Sullivan, Siobhan Saravanan, Kethar Scammell, Alastair Rao, Sudhakar Schmitt, Bernhard Schubert-Bast, Susanne Scott, David J Scott, Fraser Pye, Matthew Shah, Ayaz Stephen, Elma Shah, Shambhu Butterfill, Andrew Shute, Pauline Singh, Rajeeva Allogoa, Brigid Singh, Ravinder Sinha, Gyanranjan Sivakumar, Puthuval Smith, Robert Sriskandan, Sivaranjini Steinert, Martin Strassburg, Michael Strozzi, Susi Subramanian, Geeta Tandy, Andrew
Source :
The Lancet Child & Adolescent Health; October 2018, Vol. 2 Issue: 10 p715-725, 11p
Publication Year :
2018
Abstract
Infantile spasms constitute a severe form of epileptic encephalopathy. In the International Collaborative Infantile Spasms Study (ICISS), we showed that combining vigabatrin with hormonal therapy was more effective than hormonal therapy alone at stopping spasms between days 14 and 42 of treatment. In this planned follow-up, we aimed to assess whether combination therapy was associated with improved developmental and epilepsy outcomes at 18 months of age.
Details
Language :
English
ISSN :
23524642 and 23524650
Volume :
2
Issue :
10
Database :
Supplemental Index
Journal :
The Lancet Child & Adolescent Health
Publication Type :
Periodical
Accession number :
ejs46542482
Full Text :
https://doi.org/10.1016/S2352-4642(18)30244-X