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Snapshot summary of diagnosis and management of hepatocellular adenoma subtypes

Authors :
Bioulac-Sage, Paulette
Sempoux, Christine
Frulio, Nora
Le Bail, Brigitte
Blanc, Jean Frédéric
Castain, Claire
Laurent, Christophe
Trillaud, Hervé
Chiche, Laurence
Balabaud, Charles
Source :
Clinics and Research in Hepatology and Gastroenterology; 20240101, Issue: Preprints
Publication Year :
2024

Abstract

Hepatocellular adenomas (HCA) are rare benign hepatocellular tumors occurring mainly in women taking oral contraceptives with 2 major complications: severe bleeding and malignant transformation that can be avoided if nodules exceeding 5 cm are resected. This simple attitude has been challenged in the recent years with HCA in men, in young adolescent, in aged persons, and complications in hepatocellular adenomas below 5 cm. The discovery of specific mutations leading to specific phenotypes has modified the clinical spectrum of the disease. The phenotypic immune classification of HCA based on the molecular classification is being widely used in liver referral centers. The aim of this snapshot is to briefly present for each subtype the clinical, pathological, immuno-pathological criteria as well as the risk of complications and guidelines for treatment and management.

Details

Language :
English
ISSN :
22107401
Issue :
Preprints
Database :
Supplemental Index
Journal :
Clinics and Research in Hepatology and Gastroenterology
Publication Type :
Periodical
Accession number :
ejs46501107
Full Text :
https://doi.org/10.1016/j.clinre.2018.07.007