Back to Search
Start Over
Alkoxide-Catalyzed Hydrosilylation of Cyclic Imides to Isoquinolines via Tandem Reduction and Rearrangement
- Source :
- Organic Letters; September 2018, Vol. 20 Issue: 18 p5610-5613, 4p
- Publication Year :
- 2018
-
Abstract
- An alkoxide-catalyzed hydrosilylation of cyclic imides to isoquinolines was realized via tandem reduction and rearrangement. Using TMSOK as the catalyst and (EtO)2MeSiH as the reductant, a series of cyclic imides containing different functional groups were reduced to the corresponding 3-aryl isoquinolines in moderate to good yields. The scenario of the reaction pathway was supposed to involve the reduction of imides to ω-hydroxylactams, which underwent rearrangement in the presence of a base catalyst, and then the carbonyl reduction, followed by siloxy elimination.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 20
- Issue :
- 18
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs46414268
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b02287