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Raised plasma G-CSF and IL-6 after exercise may play a role in neutrophil mobilization into the circulation
- Source :
- Journal of Applied Physiology; May 2002, Vol. 92 Issue: 5 p1789-1794, 6p
- Publication Year :
- 2002
-
Abstract
- We examined the hypothesis that the short, intensive exercise-induced increase in circulating neutrophil counts is affected by the interaction between the endocrine and immune systems. Twelve male winter-sports athletes underwent a maximal exercise test on a treadmill. Blood samples were collected before, immediately after (Post), and 1 h (Post 1 h) and 2 h (Post 2 h) after the exercise. The neutrophil counts increased significantly at Post 1 h (P< 0.05) and remained significantly high even at Post 2 h (P< 0.05), showing a leftward shift. Plasma granulocyte colony-stimulating factor (G-CSF) increased at Post (P< 0.05), and interleukin-6 (IL-6) increased at Post 1 h (P< 0.05). Plasma G-CSF at Post significantly correlated with the numbers of both neutrophils and stab cells at Post 1 h (P< 0.05). Plasma IL-6 at Post 1 h levels also correlated significantly with the number of neutrophils at Post 2 h (P< 0.05). The increase in the levels of plasma G-CSF and IL-6 after intensive exercise may play a role in the mobilization of neutrophils into the circulatory system.
Details
- Language :
- English
- ISSN :
- 87507587 and 15221601
- Volume :
- 92
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Journal of Applied Physiology
- Publication Type :
- Periodical
- Accession number :
- ejs46244787
- Full Text :
- https://doi.org/10.1152/japplphysiol.00629.2001