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Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila

Authors :
Gorski, S.
Marra, M.
Source :
Physiological Genomics; May 2002, Vol. 9 Issue: 2 p59-69, 11p
Publication Year :
2002

Abstract

Programmed cell death (PCD) is an essential and wide-spread physiological process that results in the elimination of cells. Genes required to carry out this process have been identified, and many of these remain the subjects of intense investigation. Here, we describe PCD, its functions, and some of the consequences when it goes awry. We review PCD in the model system, the fruit fly, Drosophila melanogaster, with a particular emphasis on cell death gene discovery resulting from both genetics and genomics-based approaches.

Details

Language :
English
ISSN :
10948341 and 15312267
Volume :
9
Issue :
2
Database :
Supplemental Index
Journal :
Physiological Genomics
Publication Type :
Periodical
Accession number :
ejs46225341
Full Text :
https://doi.org/10.1152/physiolgenomics.00114.2001