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Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila
- Source :
- Physiological Genomics; May 2002, Vol. 9 Issue: 2 p59-69, 11p
- Publication Year :
- 2002
-
Abstract
- Programmed cell death (PCD) is an essential and wide-spread physiological process that results in the elimination of cells. Genes required to carry out this process have been identified, and many of these remain the subjects of intense investigation. Here, we describe PCD, its functions, and some of the consequences when it goes awry. We review PCD in the model system, the fruit fly, Drosophila melanogaster, with a particular emphasis on cell death gene discovery resulting from both genetics and genomics-based approaches.
Details
- Language :
- English
- ISSN :
- 10948341 and 15312267
- Volume :
- 9
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Physiological Genomics
- Publication Type :
- Periodical
- Accession number :
- ejs46225341
- Full Text :
- https://doi.org/10.1152/physiolgenomics.00114.2001