Effect of Aluminium oxide on inhibition activity of a deep-sea Penicillium sp. against Aspergillus parasiticus

In this study, the effects of aluminium oxide content, micro particle diameter and rotational speed on the activity of fermentation broth of deep-sea Penicillium MHE1 in inhibiting the growth of Aspergillus parasiticus NFRI-95 hypha and aflatoxin production were studied by uniform design. The optimal combination is obtained by regression analysis and experimental verification. The optimal combination is 1.015 g/L and 101.5 mesh in diameter for aluminium oxide, and 108.6 r/min for rotation incubation. Under these conditions, the mycelium inhibition rate of fermentation broth of strain MHE1 to Aspergillus parasiti NFRI-95 reached 85.88%, and the aflatoxin inhibition rate reached 100%, which increased by 7.1% and 9.2% respectively compared with that before optimization.