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Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

Authors :
Domingo, Enric
Camps, Carme
Kaisaki, Pamela J
Parsons, Marie J
Mouradov, Dmitri
Pentony, Melissa M
Makino, Seiko
Palmieri, Michelle
Ward, Robyn L
Hawkins, Nicholas J
Gibbs, Peter
Askautrud, Hanne
Oukrif, Dahmane
Wang, Haitao
Wood, Joe
Tomlinson, Evie
Bark, Yasmine
Kaur, Kulvinder
Johnstone, Elaine C
Palles, Claire
Church, David N
Novelli, Marco
Danielsen, Havard E
Sherlock, Jon
Kerr, David
Kerr, Rachel
Sieber, Oliver
Taylor, Jenny C
Tomlinson, Ian
Source :
The Lancet Gastroenterology & Hepatology; September 2018, Vol. 3 Issue: 9 p635-643, 9p
Publication Year :
2018

Abstract

Molecular indicators of colorectal cancer prognosis have been assessed in several studies, but most analyses have been restricted to a handful of markers. We aimed to identify prognostic biomarkers for colorectal cancer by sequencing panels of multiple driver genes.

Details

Language :
English
ISSN :
24681253
Volume :
3
Issue :
9
Database :
Supplemental Index
Journal :
The Lancet Gastroenterology & Hepatology
Publication Type :
Periodical
Accession number :
ejs46183173
Full Text :
https://doi.org/10.1016/S2468-1253(18)30117-1