PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia

In this study, Liu et al. investigated the molecular mechanisms regulating the proper organization and orderly mitosis of radial glial progenitors (RGPs), which drive the formation of a laminated mammalian cortex in the correct size. They show that RGP behavior and cortical development are controlled by partitioning-defective 3 (PARD3) in concert with dynamic HIPPO and NOTCH signaling regulation, thus providing new insights into mammalian cortical development.