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Simultaneous determination of antipyrine, 4- hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine in urine by gas chromatography chemical ionization mass spectrometry

Authors :
Tang, B. K.
Uchino, H.
Inaba, T.
Kalow, W.
Source :
Biomedical Mass Spectrometry; October 1982, Vol. 9 Issue: 10 p425-428, 4p
Publication Year :
1982

Abstract

A simple, accurate and precise procedure was developed to quantify, in a single run, antipyrine, 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine in urine. The stable isotope-labelled internal standards for the assay were obtained from a subject who ingested deuterium labelled antipyrine and produced urine containing the labelled drug and metabolites.

Details

Language :
English
ISSN :
0306042X
Volume :
9
Issue :
10
Database :
Supplemental Index
Journal :
Biomedical Mass Spectrometry
Publication Type :
Periodical
Accession number :
ejs45829157
Full Text :
https://doi.org/10.1002/bms.1200091004