Enantioselective α-alkylation of piperidine viachiral perhydropyrido [2,1-b] [1,3,4]-oxadiazinone: An easy route for the synthesis of both enantiomers of coniine

Enantioselective direct alkylation of piperidine involving chiral perhydropyrido [2,1-b] [1,3,4]-oxadiazinone using either form of mandelic acid as chiral auxiliary is reported. The application of the strategy is demonstrated by the synthesis of (R)- as well as (S)- coniine.