A new route to amino-2-propanol structures with adrenergic β-blocker activity using low valent titanium

Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situgenerated dihalocarbenes using LVT(Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalomethanes are the best dihalocarbene precursors. The yields obtained using halofluoromethanes can be increased by addition of carbontetrachloride. A process that can imply halogen transfer may be proposed.