Palauolol, a new anti-inflammatory sesterterpene from the sponge Fascaplysinopsissp. from Palau

A specimen of Fascaplysinopsissp. from Palau contained palauolide ( 1), fascaplysin ( 2), and a new sesterterpene, palauolol ( 3). The structure and absolute stereochemistry of palauolol ( 3) were determined using spectroscopic and chemical methods and in doing so, the absolute stereochemistry of palauolide was also determined. Palauolide ( 1) and palauolol ( 3) both inactivate bee venom phospholipase A 2.