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Intradialytic neuromuscular electrical stimulation reduces DNA damage in chronic kidney failure patients: a randomized controlled trial
- Source :
- Biomarkers; July 2018, Vol. 23 Issue: 5 p495-501, 7p
- Publication Year :
- 2018
-
Abstract
- AbstractBackground:Chronic kidney failure (CKF) patients on renal replacement therapies exhibit elevated levels of DNA lesions and this is directly related to high mortality.Objective:This study aimed to evaluate the effect of neuromuscular electrical stimulation (NMES) on genomic damage in CKF patients on conventional haemodialysis (HD).Methods:Twenty-one patients with CKF on HD were randomized into control (CG =10) or neuromuscular electrical stimulation (NMESG = 11) groups. NMES was applied on the quadriceps muscle during the HD session, three times a week, for 8 weeks in NMESG. DNA damage in blood was evaluated by the alkaline comet assay prior to follow-up, after 4 and 8 weeks of intervention.Results:Intradialytic NMES in CKF patients induced a significant decrease in DNA damage after four [49.9 (3.68) vs 101.5 (6.53); p = 0.000] than eight [19.9 (2.07) vs 101.5 (6.53); p = 0.000] weeks compared to baseline. Genomic damage was also significantly less after four [NMESG: 49.9 (3.68) vs CG: 92.9 (12.61); p = 0.001] than after eight [NMESG: 19.9 (2.07) vs CG: 76.4 (11.15); p = 0.000] weeks compared to CG.Conclusions:This study demonstrates for the first time that intradialytic NMES is able to reduce DNA damage in blood of CKF patients.
Details
- Language :
- English
- ISSN :
- 1354750x and 13665804
- Volume :
- 23
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Biomarkers
- Publication Type :
- Periodical
- Accession number :
- ejs45736148
- Full Text :
- https://doi.org/10.1080/1354750X.2018.1452049