Back to Search
Start Over
Dimethyl fumarate downregulates the immune response through the HCA2/GPR109A pathway: Implications for the treatment of multiple sclerosis
- Source :
- Multiple Sclerosis and Related Disorders; July 2018, Vol. 23 Issue: 1 p46-50, 5p
- Publication Year :
- 2018
-
Abstract
- •DMF may act in neurodegeneration and inflammation by activating the Nrf2 pathway.•DMF and MMF downregulates the immune response through HCA2/GPR109A pathway.•Nrf2 and HCA2/GPR109A pathways activation may explain DMF's efficacy and safety profile.
Details
- Language :
- English
- ISSN :
- 22110348
- Volume :
- 23
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Multiple Sclerosis and Related Disorders
- Publication Type :
- Periodical
- Accession number :
- ejs45450898
- Full Text :
- https://doi.org/10.1016/j.msard.2018.04.016