Thyroidal Status in Uremia - Effects of Hemodialysis and CAPD

Thyroid function was explored in 27 CAPD patients and 25 HD patients. Dialysis was associated with low T3and T4levels, increased rT3concentrations, normal T4: T3and reduced T4: rT3ratios, normal FT3and Thyroglobulin concentrations. TSH levels increased during dialysis but still fell within normal limits. The data rule out a condition of primary hypothyroidism and point out to increased thyroidal dismission associated with the block T4-T3in peripheral cells. Also the increased FT4levels in CAPD patients could be due to de novo dismission of thyroidal T4.