Short-term Effects of i.v. Injected Murine 99MTc-F(ab’)2Fragments of an Anti-Melanoma Antibody (HMW-MAA 225.28 S) on Haemato-Immunological Parameters in Patients with Melanoma

To evaluate alterations induced by injectedmurine radiolabelled F(ab’)2fragments of the anti HMW-MAA MoAb 225.28S on the principal haemato-immunological parameters, 32 patients with advanced malignant melanoma were studied. No statistically significant change was found after MoAb administration, but monocytes (3h after injection) and granular eosinophils (24 h after) were reduced and circulating immune complexes increased (3 h after). No toxic effect or adverse reaction was observed.Therefore, the controlled administration of purified MoAb fragments for diagnostic purposes seems to involve only a very low risk of immediate adverse reactions