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Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
Authors :
Kappos, Ludwig Bar-Or, Amit Cree, Bruce A C Fox, Robert J Giovannoni, Gavin Gold, Ralf Vermersch, Patrick Arnold, Douglas L Arnould, Sophie Scherz, Tatiana Wolf, Christian Wallström, Erik Dahlke, Frank Achiron, Anat Achtnichts, Lutz Agan, Kadriye Akman-Demir, Gulsen Allen, Alison B Antel, Jack P Antiguedad, Alfredo Rodriguez Apperson, Michelle Applebee, Angela M Ayuso, Guillermo Izquierdo Baba, Masayuki Bajenaru, Ovidiu Balasa, Rodica Balci, Belgin Petek Barnett, Michael Bass, Ann Becker, Veit U Bejinariu, Mihaela Bergh, Florian Then Bergmann, Arnfin Bernitsas, Evanthia Berthele, Achim Bhan, Virender Bischof, Felix Bjork, Randall John Blevins, Gregg Boehringer, Matthias Boerner, Thomas Bonek, Robert Bowen, James D Bowling, Allen Boyko, Alexey N Boz, Cavit Bracknies, Vera Braune, Stefan Brescia Morra, Vincenzo Brochet, Bruno Brola, Waldemar Brownstone, Paul Kenneth Brozman, Miroslav Brunet, Donald Buraga, Ioan Burnett, Margaret Buttmann, Mathias Butzkueven, Helmut Cahill, Jonathan Calkwood, Jonathan C Camu, William Cascione, Mark Castelnovo, Giovani Centonze, Diego Cerqueira, Joao Chan, Andrew Cimprichova, Andrea Cohan, Stanley Comi, Giancarlo Conway, Jill Cooper, Joanna A Corboy, John Correale, Jorge Costell, Brian Cottrell, David A Coyle, Patricia K Craner, Matthew Cui, Liying Cunha, Luis Czlonkowska, Anna da Silva, Ana Martins de Sa, Joao de Seze, Jérôme Debouverie, Marc Debruyne, Jan Decoo, Danny Defer, Gilles Derfuss, Tobias Deri, Norma H Dihenia, Bhupesh Dioszeghy, Peter Donath, Vladimir Dubois, Benedicte Duddy, Martin Duquette, Pierre Edan, Gilles Efendi, Husnu Elias, Stanton Emrich, Peter J Estruch, Bonaventura Casanova Evdoshenko, Evgeniy P Faiss, Juergen Fedyanin, Alexander S Feneberg, Wolfgang Fermont, Jiske Fernandez, Oscar Fernandez Ferrer, Francisco Coret Fink, Katharina Ford, Helen Ford, Corey Francia, Ada Freedman, Mark Frishberg, Benjamin Galgani, Simonetta Garmany, George P Gehring, Klaus Gitt, Jeffrey Gobbi, Claudio Goldstick, Lawrence P Gonzalez, Rafael Arroyo Grandmaison, Francois Grigoriadis, Nikolaos Grigorova, Olga Grimaldi, Luigi Maria Edoardo Gross, Jeffrey Gross-Paju, Katrin Gudesblatt, Mark Guillaume, Daniel Haas, Judith Hancinova, Viera Hancu, Anca Hardiman, Orla Harmjanz, Arndt Heidenreich, Fedor R Hengstman, G J D Herbert, Joseph Herring, Mark Hodgkinson, Suzanne Hoffmann, Olaf M Hofmann, Werner E Honeycutt, William D Hua, Le Hanh Huang, Dehui Huang, Yining Huang, DeRen Hupperts, Raymond Imre, Piroska Jacobs, Alan Keith Jakab, Gabor Jasinska, Elzbieta Kaida, Kenichi Kalnina, Jolanta Kaprelyan, Ara Karelis, Guntis Karussis, Dimitrios Katz, Amos Khabirov, Farit A Khatri, Bhupendra Kimura, Takashi Kister, Ilya Kizlaitiene, Rasa Klimova, Eleonora Koehler, Juergen Komatineni, Aparna Kornhuber, Anselm Kovacs, Krisztina Koves, Agnes Kozubski, Wojciech Krastev, Georgi Krupp, Lauren B Kurca, Egon Lassek, Christoph Laureys, Guy Lee, Liesly Lensch, Eckart Leutmezer, Fritz Li, Hongzeng Linker, Ralf A Linnebank, Michael Liskova, Petra Llanera, Cristina Lu, Jiahong Lutterotti, Andreas Lycke, Jan Macdonell, Richard Maciejowski, Maciej Maeurer, Mathias Magzhanov, Rim V Maida, Eva-Maria Malciene, Lina Mao-Draayer, Yang Marfia, Girolama Alessandra Markowitz, Clyde Mastorodimos, Vasileios Matyas, Klotild Meca-Lallana, Jose Merino, Juan Antonio Garcia Mihetiu, Ioan Gheorghe Milanov, Ivan Miller, Aaron E Millers, Andrejs Mirabella, Massimiliano Mizuno, Masanori Montalban, Xavier Montoya, Lilina Mori, Masahiro Mueller, Stefanie Nakahara, Jin Nakatsuji, Yuji Newsome, Scott Nicholas, Richard Nielsen, A Scott Nikfekr, Esmaeil Nocentini, Ugo Nohara, Chiyoko Nomura, Kyoichi Odinak, Miroslav M Olsson, Tomas van Oosten, B W Oreja-Guevara, Celia Oschmann, Patrick Overell, James Pachner, Andrew Panczel, Gyula Pandolfo, Massimo Papeix, Caroline Patrucco, Liliana Pelletier, Jean Piedrabuena, Raul Pless, Misha Polzer, Udo Pozsegovits, Krisztian Rastenyte, Daiva Rauer, Sebastian Reifschneider, Gerd Rey, Roberto Rizvi, Syed A Robertson, Derrick Rodriguez, Jose Martinez Rog, David Roshanisefat, Homayoun Rowe, Vernon Rozsa, Csilla Rubin, Susan Rusek, Stanislaw Saccà, Francesco Saida, Takahiko Salgado, Antonio Vasco Sanchez, Victoria Eugenia Fernandez Sanders, Kalina Satori, Maria Sazonov, Denis V Scarpini, Elio Angelo Schlegel, Eugen Schluep, Myriam Schmidt, Stephan Scholz, Erich Schrijver, H M Schwab, Matthias Schwartz, Raymond Scott, James Selmaj, Krzysztof Shafer, Stuart Sharrack, Basil Shchukin, Ivan A Shimizu, Yuko Shotekov, Penko Siever, Arno Sigel, Karl-Otto Silliman, Scott Simo, Magdolna Simu, Mihaela Sinay, Vladimiro Siquier, Antonio Escartin Siva, Aksel Skoda, Ondrej Solomon, Andrew Stangel, Martin Stefoski, Dusan Steingo, Brian Stolyarov, Igor D Stourac, Pavel Strassburger-Krogias, Katrin Strauss, Erik Stuve, Olaf Tarnev, Ivaylo Tavernarakis, Antonios Tello, Cristina Ramo Terzi, Murat Ticha, Veronika Ticmeanu, Marina Tiel-Wilck, Klaus Toomsoo, Toomas Tubridy, Niall Tullman, Mark J Tumani, Hayrettin Turcani, Peter Turner, Ben Uccelli, Antonio Urtaza, Francisco Javier Olascoaga Vachova, Marta Valikovics, Attila Walter, Silke Van Wijmeersch, Bart Vanopdenbosch, Ludo Weber, Joerg R Weiss, Sara Weissert, Robert Vermersch, Patrick West, Timothy Wiendl, Heinz Wiertlewski, Sandrine Wildemann, Brigitte Willekens, Barbara Visser, L H Vorobeychik, Galina Xu, Xianhao Yamamura, Takashi Yang, Yi N Yelamos, Sergio Martinez Yeung, Michael Zacharias, Alan Zelkowitz, Marvin Zettl, Uwe Zhang, Meini Zhou, Hongyu Zieman, Ulf Ziemssen, Tjalf
Source :
The Lancet; March 2018, Vol. 391 Issue: 10127 p1263-1273, 11p
Publication Year :
2018
Abstract
No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) receptor1,5modulator, on disability progression in patients with SPMS.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
391
Issue :
10127
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs45240845
Full Text :
https://doi.org/10.1016/S0140-6736(18)30475-6