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Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
- Source :
- Science Signaling; March 2018, Vol. 11 Issue: 521
- Publication Year :
- 2018
-
Abstract
- Resistance to PI3K inhibitors in triple-negative breast cancer is mediated by AKT reactivation by the ubiquitin ligase Skp2.
Details
- Language :
- English
- ISSN :
- 19450877 and 19379145
- Volume :
- 11
- Issue :
- 521
- Database :
- Supplemental Index
- Journal :
- Science Signaling
- Publication Type :
- Periodical
- Accession number :
- ejs45046321
- Full Text :
- https://doi.org/10.1126/scisignal.aao3810