4CPS-012 Pharmacotherapeutical profile before and after liver transplantation

BackgroundPatients undergoing liver transplantation require pharmacological treatment indefinitely and some patients have complications related to this treatment (diabetes, high cholesterol, high blood pressure, impaired renal function, osteoporosis).PurposeTo evaluate and analyse the quantitative difference in the number of drugs after liver transplantation.Material and methodsA longitudinal observational study with prospective data collection and usual clinical practice of the series of cases undergoing liver transplantation over a 2 year period (2016–2017). The data collected were: sex, age, cause of transplantation, number of drugs before and after transplantation.The data have been extracted from the electronic medical record through the Selene®program and we used descriptive statistic using the SPSS®V23 program.ResultsDuring this study period, 71 patients underwent liver transplantation in our hospital, of which 67.6% were men, the mean age was 53±11 years. The main causes of liver transplantation were: 34.2% alcoholic liver cirrhosis, 22.9% hepatic cirrhosis associated with the hepatitis C virus and 10% hepatic biliary cirrhosis. The mean number of medications taken by these patients was 4.92±3, while the mean in the hospital discharge was 11.71±2.Thirty-three patients (48. 5%) had to stop all treatment prior to transplantation, one patient had already been transplanted and 50% kept only one or two drugs (omeprazole, calcium-vitamin D supplement, levothyroxine, tenofovir, acetylsalicylic acid as antiaggregant).After undergoing transplantation, 16.7% of patients had high blood pressure and 50% had diabetes mellitus that required insulin administration.All patients were discharged from the hospital with hospital diagnosis medicines with an average of 2.65±0, 54 medicines and 36.4% with hospital-use medicines. 4. 3% of the patients not got over the transplantation.ConclusionThe increase in the number of drugs after liver transplantation is significant, moreover the administration and dispensing conditions of some of the drugs have a greater complexity, especially immunosuppressants and insulin, so these patients should receive pharmaceutical care.References and/or AcknowledgementsThanks to my service for your unconditional support.No conflict of interest