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Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons
- Source :
- Cell Reports; January 2018, Vol. 22 Issue: 1 p36-43, 8p
- Publication Year :
- 2018
-
Abstract
- Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAAand metabotropic GABABreceptors (GABABRs). Despite GABABRs representing a major source of inhibition, little is known of their function in distinct IN subtypes. Here, we show that, while the archetypal dendritic-inhibitory somatostatin-expressing INs (SOM-INs) possess high levels of GABABR on their somato-dendritic surface, they fail to produce significant postsynaptic inhibitory currents. Instead, GABABRs selectively inhibit dendritic CaV1.2 (L-type) Ca2+channels on SOM-IN dendrites, leading to reduced calcium influx and loss of long-term potentiation at excitatory input synapses onto these INs. These data provide a mechanism by which GABABRs can contribute to disinhibition and control the efficacy of extrinsic inputs to hippocampal networks.
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 22
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Cell Reports
- Publication Type :
- Periodical
- Accession number :
- ejs44414029
- Full Text :
- https://doi.org/10.1016/j.celrep.2017.12.021