Back to Search
Start Over
Self‐eating and self‐defense: autophagy controls innate immunity and adaptive immunity
- Source :
- Journal of Leukocyte Biology; April 2013, Vol. 93 Issue: 4 p511-519, 9p
- Publication Year :
- 2013
-
Abstract
- Review on how the self‐eating (autophagy) process could regulate the self‐defense (immune) system. Autophagy (macroautophagy; “self‐eating”) is a degradation process, in which cytoplasmic content is engulfed and degraded by the lysosome. And, immunity is an important mechanism of the “self‐defense” system. Autophagy has long been recognized as a stress response to nutrient deprivation. This will provide energy and anabolic building blocks to maintain cellular bioenergetic homeostasis. Thus, autophagy plays critical roles in regulating a wide variety of pathophysiological processes, including tumorigenesis, embryo development, tissue remodeling, and most recently, immunity. The latter shows that a self‐eating (autophagy) process could regulate a self‐defense (immune) system. In this review, we summarize the recent findings regarding the regulatory and mechanistic insights of the autophagy pathway in immunity.
Details
- Language :
- English
- ISSN :
- 07415400 and 19383673
- Volume :
- 93
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Journal of Leukocyte Biology
- Publication Type :
- Periodical
- Accession number :
- ejs44386704
- Full Text :
- https://doi.org/10.1189/jlb.0812389