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Cell type‐ and stimulus‐specific mechanisms for post‐transcriptional control of neutrophil chemokine gene expression
- Source :
- Journal of Leukocyte Biology; March 2012, Vol. 91 Issue: 3 p377-383, 7p
- Publication Year :
- 2012
-
Abstract
- Review on chemokine gene expression and its control by multiple post‐transcriptional mechanisms that exhibit differential cell type utilization and stimulus dependency. mRNAs encoding inflammatory chemokines that recruit neutrophils frequently exhibit short half‐lives that serve to limit their expression under inappropriate conditions but are often prolonged to ensure adequate levels during inflammatory response. Extracellular stimuli that modulate the stability of such mRNAs may be the same as the transcriptional activator, as is the case with TLR ligands, or may cooperate with independent transcriptional stimuli, as with IL‐17, which extends the half‐life of TNF‐induced transcripts. These different stimuli engage independent signaling pathways that target different instability mechanisms distinguished by dependence on different regulatory nucleotide sequence motifs within the 3′UTRs, which involve that action of different mRNA‐binding proteins. The selective use of these pathways by different stimuli and in distinct cell populations provides the potential for tailoring of chemokine expression patterns to meet specific needs in different pathophysiologic circumstances.
Details
- Language :
- English
- ISSN :
- 07415400 and 19383673
- Volume :
- 91
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Leukocyte Biology
- Publication Type :
- Periodical
- Accession number :
- ejs44386365
- Full Text :
- https://doi.org/10.1189/jlb.0811404