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Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

Authors :
Schechter, Melissa E.
Andrade, Bruno B.
He, Tianyu
Richter, George Haret
Tosh, Kevin W.
Policicchio, Benjamin B.
Singh, Amrit
Raehtz, Kevin D.
Sheikh, Virginia
Ma, Dongying
Brocca-Cofano, Egidio
Apetrei, Cristian
Tracy, Russel
Ribeiro, Ruy M.
Sher, Alan
Francischetti, Ivo M. B.
Pandrea, Ivona
Sereti, Irini
Source :
Science Translational Medicine; August 2017, Vol. 9 Issue: 405
Publication Year :
2017

Abstract

Activated monocytes in blood promote chronic inflammation and persistent coagulation in HIV-infected patients and SIV-infected macaques.

Details

Language :
English
ISSN :
19466234 and 19466242
Volume :
9
Issue :
405
Database :
Supplemental Index
Journal :
Science Translational Medicine
Publication Type :
Periodical
Accession number :
ejs43105208
Full Text :
https://doi.org/10.1126/scitranslmed.aam5441