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Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

Authors :
Scicluna, Brendon P
van Vught, Lonneke A
Zwinderman, Aeilko H
Wiewel, Maryse A
Davenport, Emma E
Burnham, Katie L
Nürnberg, Peter
Schultz, Marcus J
Horn, Janneke
Cremer, Olaf L
Bonten, Marc J
Hinds, Charles J
Wong, Hector R
Knight, Julian C
van der Poll, Tom
de Beer, Friso M.
Bos, Lieuwe D.J.
Frencken, Jos F.
Koster-Brouwer, Maria E.
van de Groep, Kirsten
Verboom, Diana M.
Glas, Gerie J.
van Hooijdonk, Roosmarijn T.M.
Hoogendijk, Arie J.
Huson, Mischa A.
Klouwenberg, Peter M. Klein
Ong, David S.Y.
Schouten, Laura R.A.
Straat, Marleen
Witteveen, Esther
Wieske, Luuk
Source :
The Lancet Respiratory Medicine; October 2017, Vol. 5 Issue: 10 p816-826, 11p
Publication Year :
2017

Abstract

Host responses during sepsis are highly heterogeneous, which hampers the identification of patients at high risk of mortality and their selection for targeted therapies. In this study, we aimed to identify biologically relevant molecular endotypes in patients with sepsis.

Details

Language :
English
ISSN :
22132600 and 22132619
Volume :
5
Issue :
10
Database :
Supplemental Index
Journal :
The Lancet Respiratory Medicine
Publication Type :
Periodical
Accession number :
ejs43067009
Full Text :
https://doi.org/10.1016/S2213-2600(17)30294-1