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General Principles and Strategies for Salting-Out Informed by the Hofmeister Series
- Source :
- Organic Process Research & Development; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- Overarching principles for salting-out extraction are long-established but poorly disseminated. We highlight the opportunity for more widespread application of this technique using the Hofmeister series as a foundational basis for choosing the right salt. The power of this approach is exemplified by the aqueous workup of a highly water-soluble nucleoside in which the use of sodium sulfate allowed for high recoveries without relying on back extraction.
Details
- Language :
- English
- ISSN :
- 10836160 and 1520586X
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Organic Process Research & Development
- Publication Type :
- Periodical
- Accession number :
- ejs42971073
- Full Text :
- https://doi.org/10.1021/acs.oprd.7b00197