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Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
- Source :
- Science Translational Medicine; June 2017, Vol. 9 Issue: 394
- Publication Year :
- 2017
-
Abstract
- AZD4785 is a therapeutic antisense oligonucleotide targeting KRAS mRNA with promising preclinical antitumor activity and a favorable safety profile.
Details
- Language :
- English
- ISSN :
- 19466234 and 19466242
- Volume :
- 9
- Issue :
- 394
- Database :
- Supplemental Index
- Journal :
- Science Translational Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs42588474
- Full Text :
- https://doi.org/10.1126/scitranslmed.aal5253