Oxygen-Ozone Therapy and Amitriptyline in Disc Diseases and Herniated Intervertebral Discs

Nowadays there are several treatments to deal with disc-articular diseases as well as acute and chronic pain; they are all aimed at accelerating the resolution of symptoms, minimizing the psychological and occupational impact, preventing relapses and chronic situations.A new treatment for disc-articular conflicts is oxygen-ozone therapy, which gives good results in 90% of cases. All the patients with vertebral disease treated followed the national protocol S100T 953902 for a multicentric controlled evaluation, in perspective and at random, of oxygen-ozone therapy impact by intramuscular injection into the slipped disc. Patients' compliance with O2-O3therapy is good and complications in administering O2-O3mixture are not recorded, either at a local level (allergic reactions or implications) or at a general level (anaphylactic shock, hepatic or renal complications).Some cases were simultaneously treated with oxygen-ozone therapy and amitriptyline and a more rapid improvement was noted, either concerning pain or slipped disc reduction, as well as improved mood (considering that alteration of mood is frequent in patients with painful disease).